Assay Detail
Functional
CHEMBL4731048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse MC5R by alphascreen cAMP assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peptoid NPhe in AGRP-Based c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Scaffolds Maintain Mouse MC4R Antagonist Potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.11 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.96 |
| CHEMBL4764556 | — | — | 1 | 6.26 |
| CHEMBL4743564 | — | — | 1 | - |
| CHEMBL4754305 | — | — | 1 | - |
| CHEMBL4785157 | — | — | 1 | - |
| CHEMBL4762178 | — | — | 1 | - |
| CHEMBL4797774 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL4764556 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4743564 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4754305 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4785157 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4762178 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4797774 | — | EC50 | > | 100000.0 | nM | - |