Assay Detail
Functional
CHEMBL4731050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse MC5R assessed as antagonist potency by alphascreen cAMP assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peptoid NPhe in AGRP-Based c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Scaffolds Maintain Mouse MC4R Antagonist Potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.85 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4102048 | — | — | 1 | 7.50 |
| CHEMBL4747952 | — | — | 1 | 7.40 |
| CHEMBL3577981 | — | — | 1 | 6.40 |
| CHEMBL4740561 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4102048 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL4747952 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL3577981 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL4740561 | — | Kd | = | 794.33 | nM | 6.10 |