Assay Detail
Binding
CHEMBL4731052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity pig brain GABA-AT assessed as inactivation constant using GABA as substrate in presence of NADP+ and alpha-ketoglutarate by SSDH coupled enzyme based UV-Vis spectrophotometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
4-aminobutyrate aminotransferase, mitochondrial (CHEMBL2266) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.52 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4746439 | — | — | 1 | 5.00 |
| CHEMBL4747359 | — | — | 1 | 4.58 |
| CHEMBL163117 | — | — | 1 | 4.28 |
| CHEMBL146927 | CPP-115 FREE BASE | 1.0 | 1 | 4.23 |
| CHEMBL4758952 | — | — | 1 | - |
| CHEMBL4741430 | — | — | 1 | - |
| CHEMBL89598 | VIGABATRIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4746439 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4747359 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL163117 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL146927 | CPP-115 FREE BASE | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL4758952 | — | Ki | = | 6010000.0 | nM | - |
| CHEMBL4741430 | — | Ki | = | 14260000.0 | nM | - |
| CHEMBL89598 | VIGABATRIN | Ki | = | 290000.0 | nM | - |