Assay Detail
Binding
CHEMBL4731082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(R)-(+)-7-OH-DPAT from human D3 receptor expressed in HEK293 cells after 90 mins by microbeta counting based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine DR Bitopic Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.37 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70565 | — | — | 1 | 8.78 |
| CHEMBL4744811 | — | — | 1 | 7.67 |
| CHEMBL4764883 | — | — | 1 | 6.37 |
| CHEMBL4778398 | — | — | 1 | 5.26 |
| CHEMBL97424 | — | — | 1 | 5.25 |
| CHEMBL4791884 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70565 | — | Ki | = | 1.67 | nM | 8.78 |
| CHEMBL4744811 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL4764883 | — | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL4778398 | — | Ki | = | 5540.0 | nM | 5.26 |
| CHEMBL97424 | — | Ki | = | 5620.0 | nM | 5.25 |
| CHEMBL4791884 | — | Ki | = | 13800.0 | nM | 4.86 |