Assay Detail
Binding
CHEMBL4731087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 protease by fluorescence based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.32 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4800615 | — | — | 1 | 10.66 |
| CHEMBL4743665 | — | — | 1 | 10.52 |
| CHEMBL4744116 | — | — | 1 | 10.49 |
| CHEMBL4740468 | — | — | 1 | 10.18 |
| CHEMBL256107 | — | — | 1 | 9.55 |
| CHEMBL4763723 | — | — | 1 | 8.84 |
| CHEMBL4764958 | — | — | 1 | 7.76 |
| CHEMBL4784475 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4800615 | — | Ki | = | 0.022 | nM | 10.66 |
| CHEMBL4743665 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL4744116 | — | Ki | = | 0.032 | nM | 10.49 |
| CHEMBL4740468 | — | Ki | = | 0.066 | nM | 10.18 |
| CHEMBL256107 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL4763723 | — | Ki | = | 1.45 | nM | 8.84 |
| CHEMBL4764958 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL4784475 | — | Ki | = | 284.0 | nM | 6.55 |