Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4731363

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Venezuelan equine encephalitis virus TC-83 infected in mouse Neuro-2a cells pretreated with compound for 2 hrs followed by viral infection at MOI of 3.5 and measured after 7 hrs by immunostaining based confocal microscopic analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Venezuelan equine encephalitis virus
Cell Type N2a
Confidence 1 — Organism
Curated By Autocuration

Target

Venezuelan equine encephalitis virus (CHEMBL613726)
Type ORGANISM
Organism Venezuelan equine encephalitis virus

Publication

Vinyl Sulfone-Based Inhibitors of Nonstructural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus.
Zhang H,Harmon M,Radoshitzky SR,Soloveva V,Kane CD,Duplantier AJ,Ogungbe IV
ACS Med Chem Lett (2020) 11 : 2139 -2145
PubMed 33214821 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 5.37 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4748176 1 7.70
CHEMBL4760407 1 5.70
CHEMBL4759030 1 5.47
CHEMBL4758975 1 5.43
CHEMBL4753529 1 5.30
CHEMBL4748474 1 4.96
CHEMBL4751121 1 4.89
CHEMBL4794421 1 4.89
CHEMBL4641959 1 4.72
CHEMBL4785387 1 4.66
CHEMBL4782964 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4748176 EC50 = 20.0 nM 7.70
CHEMBL4760407 EC50 = 2000.0 nM 5.70
CHEMBL4759030 EC50 = 3400.0 nM 5.47
CHEMBL4758975 EC50 = 3700.0 nM 5.43
CHEMBL4753529 EC50 = 5000.0 nM 5.30
CHEMBL4748474 EC50 = 11000.0 nM 4.96
CHEMBL4751121 EC50 = 13000.0 nM 4.89
CHEMBL4794421 EC50 = 13000.0 nM 4.89
CHEMBL4641959 EC50 = 19000.0 nM 4.72
CHEMBL4785387 EC50 = 22000.0 nM 4.66
CHEMBL4782964 EC50 > 25000.0 nM -