Assay Detail
Functional
CHEMBL4731443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-ferroptotic activity in FRDA patient-derived Lymphocyte assessed as reduction in RSL3-induced lipid peroxidation incubated for overnight followed by RSL3 stimulation and measured after 90 mins by FACS analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Lymphocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.51 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776014 | — | — | 1 | 8.05 |
| CHEMBL4760943 | — | — | 1 | 7.92 |
| CHEMBL4780114 | — | — | 1 | 7.85 |
| CHEMBL4748297 | — | — | 1 | 7.80 |
| CHEMBL2094750 | — | — | 1 | 7.66 |
| CHEMBL4284807 | — | — | 1 | 7.60 |
| CHEMBL1713097 | — | — | 1 | 7.58 |
| CHEMBL4743169 | — | — | 1 | 7.42 |
| CHEMBL3633556 | — | — | 1 | 7.32 |
| CHEMBL4794302 | — | — | 1 | 7.28 |
| CHEMBL4786190 | — | — | 1 | 7.27 |
| CHEMBL4129965 | — | — | 1 | 7.16 |
| CHEMBL4743688 | — | — | 1 | 7.12 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 7.06 |
| CHEMBL4789463 | — | — | 1 | - |
| CHEMBL47 | ALPHA-TOCOPHEROL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776014 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4760943 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4780114 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4748297 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2094750 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4284807 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1713097 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4743169 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3633556 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4794302 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4786190 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4129965 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4743688 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4789463 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL47 | ALPHA-TOCOPHEROL | EC50 | > | 500.0 | nM | - |