Assay Detail
Functional
CHEMBL4731444
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of erastin-induced cell death in FRDA patient-derived fibroblast assessed as depletion of cellular ATP incubated for 12 hrs followed by erastin stimulation and measured after by luciferase-linked ATPase enzymatic assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.60 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776014 | — | — | 1 | 8.00 |
| CHEMBL4760943 | — | — | 1 | 7.96 |
| CHEMBL4780114 | — | — | 1 | 7.82 |
| CHEMBL4748297 | — | — | 1 | 7.82 |
| CHEMBL4284807 | — | — | 1 | 7.66 |
| CHEMBL2094750 | — | — | 1 | 7.66 |
| CHEMBL1713097 | — | — | 1 | 7.57 |
| CHEMBL4743169 | — | — | 1 | 7.54 |
| CHEMBL3633556 | — | — | 1 | 7.48 |
| CHEMBL4786190 | — | — | 1 | 7.46 |
| CHEMBL4794302 | — | — | 1 | 7.43 |
| CHEMBL4743688 | — | — | 1 | 7.41 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 7.37 |
| CHEMBL4129965 | — | — | 1 | 7.26 |
| CHEMBL47 | ALPHA-TOCOPHEROL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776014 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4760943 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4780114 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4748297 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4284807 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2094750 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1713097 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4743169 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3633556 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4786190 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4794302 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4743688 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4129965 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL47 | ALPHA-TOCOPHEROL | EC50 | > | 500.0 | nM | - |