Assay Detail
Functional
CHEMBL4731599
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Cytotoxicity against human BCWM1 cells expressing MYD88 mutant assessed as cell killing measured after 72 hrs by CellTiter-Glo luminescent cell viability assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BCWM1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Selective, Covalent IRAK1 Inhibitor with Antiproliferative Activity in MYD88 Mutated B-Cell Lymphoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.28 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4782804 | — | — | 1 | 5.99 |
| CHEMBL4799481 | — | — | 1 | 5.59 |
| CHEMBL4790193 | — | — | 1 | 5.25 |
| CHEMBL4784448 | — | — | 1 | 4.89 |
| CHEMBL4781702 | — | — | 1 | 4.70 |
| CHEMBL4786242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4782804 | — | EC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4799481 | — | EC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4790193 | — | EC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL4784448 | — | EC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4781702 | — | EC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL4786242 | — | EC50 | = | 418000.0 | nM | - |