Assay Detail

CHEMBL4731697

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of Escherichia coli chromosomal Dfr

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Escherichia coli
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.

Toulouse JL,Shi G,Lemay-St-Denis C,Ebert MCCJC,Deon D,Gagnon M,Ruediger E,Saint-Jacques K,Forge D,Vanden Eynde JJ,Marinier A,Ji X,Pelletier JN
ACS Med Chem Lett (2020) 11 : 2261 -2267
PubMed 33214838 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.70	10.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL22	TRIMETHOPRIM	4.0	1	10.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL22	TRIMETHOPRIM	Ki	=	0.02	nM	10.70