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Assay Detail

CHEMBL4732282

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human MCF-7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of pyrazole-linked aloe emodin derivatives as potential anticancer agents
Kumar, Guddeti Dileep, Siva, Bandi, Vadlamudi, Sravanthi, Bathula, Surendar Reddy, Dutta, Hashnu, Suresh Babu, K.
RSC Med Chem (2021) 12 : 791 -796
PubMed 34124677 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.52 6.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4764590 1 6.06
CHEMBL4762521 1 6.00
CHEMBL4780404 1 5.98
CHEMBL4762790 1 5.95
CHEMBL4776612 1 5.94
CHEMBL53463 DOXORUBICIN 4.0 1 5.70
CHEMBL2338661 1 5.57
CHEMBL4749579 1 5.57
CHEMBL4749145 1 5.50
CHEMBL4753858 1 5.45
CHEMBL4786941 1 5.41
CHEMBL4762581 1 5.40
CHEMBL40275 ALOE-EMODIN 1 5.38
CHEMBL4793827 1 5.33
CHEMBL4743986 1 5.33
CHEMBL4760752 1 5.20
CHEMBL4752716 1 5.14
CHEMBL4796494 1 5.05
CHEMBL4743262 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4764590 IC50 = 870.0 nM 6.06
CHEMBL4762521 IC50 = 990.0 nM 6.00
CHEMBL4780404 IC50 = 1040.0 nM 5.98
CHEMBL4762790 IC50 = 1130.0 nM 5.95
CHEMBL4776612 IC50 = 1160.0 nM 5.94
CHEMBL53463 DOXORUBICIN IC50 = 2020.0 nM 5.70
CHEMBL2338661 IC50 = 2680.0 nM 5.57
CHEMBL4749579 IC50 = 2680.0 nM 5.57
CHEMBL4749145 IC50 = 3180.0 nM 5.50
CHEMBL4753858 IC50 = 3580.0 nM 5.45
CHEMBL4786941 IC50 = 3860.0 nM 5.41
CHEMBL4762581 IC50 = 3960.0 nM 5.40
CHEMBL40275 ALOE-EMODIN IC50 = 4140.0 nM 5.38
CHEMBL4793827 IC50 = 4620.0 nM 5.33
CHEMBL4743986 IC50 = 4660.0 nM 5.33
CHEMBL4760752 IC50 = 6350.0 nM 5.20
CHEMBL4752716 IC50 = 7260.0 nM 5.14
CHEMBL4796494 IC50 = 8980.0 nM 5.05
CHEMBL4743262 IC50 = 9960.0 nM 5.00