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Assay Detail

CHEMBL4732284

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against mouse B16-F10 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type B16-F10
Confidence 1 — Organism
Curated By Autocuration

Target

B16-F10 (CHEMBL612656)
Type CELL-LINE
Organism Mus musculus

Publication

Design, synthesis, and biological evaluation of pyrazole-linked aloe emodin derivatives as potential anticancer agents
Kumar, Guddeti Dileep, Siva, Bandi, Vadlamudi, Sravanthi, Bathula, Surendar Reddy, Dutta, Hashnu, Suresh Babu, K.
RSC Med Chem (2021) 12 : 791 -796
PubMed 34124677 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.46 5.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4764590 1 5.94
CHEMBL4762790 1 5.80
CHEMBL4780404 1 5.73
CHEMBL4786941 1 5.67
CHEMBL4749145 1 5.65
CHEMBL2338661 1 5.54
CHEMBL40275 ALOE-EMODIN 1 5.51
CHEMBL53463 DOXORUBICIN 4.0 1 5.48
CHEMBL4743986 1 5.48
CHEMBL4753858 1 5.47
CHEMBL4793827 1 5.46
CHEMBL4760752 1 5.46
CHEMBL4762581 1 5.41
CHEMBL4752716 1 5.27
CHEMBL4743262 1 5.25
CHEMBL4749579 1 5.22
CHEMBL4776612 1 5.21
CHEMBL4796494 1 5.09
CHEMBL4762521 1 5.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4764590 IC50 = 1150.0 nM 5.94
CHEMBL4762790 IC50 = 1570.0 nM 5.80
CHEMBL4780404 IC50 = 1850.0 nM 5.73
CHEMBL4786941 IC50 = 2150.0 nM 5.67
CHEMBL4749145 IC50 = 2220.0 nM 5.65
CHEMBL2338661 IC50 = 2900.0 nM 5.54
CHEMBL40275 ALOE-EMODIN IC50 = 3120.0 nM 5.51
CHEMBL53463 DOXORUBICIN IC50 = 3280.0 nM 5.48
CHEMBL4743986 IC50 = 3340.0 nM 5.48
CHEMBL4753858 IC50 = 3350.0 nM 5.47
CHEMBL4793827 IC50 = 3460.0 nM 5.46
CHEMBL4760752 IC50 = 3460.0 nM 5.46
CHEMBL4762581 IC50 = 3900.0 nM 5.41
CHEMBL4752716 IC50 = 5400.0 nM 5.27
CHEMBL4743262 IC50 = 5610.0 nM 5.25
CHEMBL4749579 IC50 = 6060.0 nM 5.22
CHEMBL4776612 IC50 = 6090.0 nM 5.21
CHEMBL4796494 IC50 = 8150.0 nM 5.09
CHEMBL4762521 IC50 = 9570.0 nM 5.02