Assay Detail
Functional
CHEMBL4732607
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Cytotoxicity against human HeLa cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.18 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232279 | NEMORUBICIN | 2.0 | 1 | 7.10 |
| CHEMBL4793704 | — | — | 1 | 6.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.43 |
| CHEMBL3289398 | — | — | 1 | 6.34 |
| CHEMBL3989407 | QUARFLOXIN | 2.0 | 1 | 5.35 |
| CHEMBL4303309 | CX-5461 | 1.0 | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232279 | NEMORUBICIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4793704 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL3289398 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3989407 | QUARFLOXIN | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL4303309 | CX-5461 | IC50 | = | 6890.0 | nM | 5.16 |