Assay Detail

CHEMBL4732983

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Functional

Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by MTT assay

ChEMBL ↗

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Target

MDA-MB-231 (CHEMBL400) ↗

Open DB target context

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MDA-MB-231 (CHEMBL400) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MDA-MB-231

CHEMBL400

Anchored from Assay target.

Protein identity MDA-MB-231

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MDA-MB-231
Confidence	1 — Organism
Curated By	Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.

Kumari S,Carmona AV,Tiwari AK,Trippier PC
J Med Chem (2020) 63 : 12290 -12358
PubMed 32686940 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	4.06	4.06

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4762551	—	—	1	4.06
CHEMBL294199	CAPSAICIN	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4762551	—	IC50	=	87000.0	nM	4.06
CHEMBL294199	CAPSAICIN	IC50	=	120000.0	nM	-