Assay Detail
ADMET
CHEMBL4733111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE3A using cAMP as substrate incubated for 20 mins measured by Kinase Glo reagent based microplate reader assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (CHEMBL241) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.08 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189 | MILRINONE | 4.0 | 1 | 6.60 |
| CHEMBL4787162 | — | — | 1 | 5.00 |
| CHEMBL4784075 | — | — | 1 | 4.39 |
| CHEMBL4762789 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189 | MILRINONE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4787162 | — | IC50 | = | 9920.0 | nM | 5.00 |
| CHEMBL4784075 | — | IC50 | = | 40640.0 | nM | 4.39 |
| CHEMBL4762789 | — | IC50 | = | 47280.0 | nM | 4.33 |