Assay Detail
Functional
CHEMBL4733240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells assessed as cell viability after 24 hrs by Celltiter-Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.30 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4798567 | — | — | 1 | 8.35 |
| CHEMBL498271 | — | — | 1 | 8.28 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4798567 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL498271 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5.5 | nM | 8.26 |