Assay Detail
Binding
CHEMBL4733337
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Inhibition of N-terminal His-tagged human p300 HAT (1319 to 1710 residues) expressed in Escherichia coli using histone H3 (1 to 21 residues) as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Current development of CBP/p300 inhibitors in the last decade.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.25 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106011 | — | — | 1 | 5.27 |
| CHEMBL1795624 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106011 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL1795624 | — | IC50 | = | 5920.0 | nM | 5.23 |