Assay Detail
ADMET
CHEMBL4733432
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Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, binding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective σR/TMEM97 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.67 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4778965 | — | — | 1 | 5.01 |
| CHEMBL4765186 | — | — | 1 | 4.63 |
| CHEMBL4749663 | — | — | 1 | 4.56 |
| CHEMBL4746910 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778965 | — | IC50 | = | 9770.0 | nM | 5.01 |
| CHEMBL4765186 | — | IC50 | = | 23490.0 | nM | 4.63 |
| CHEMBL4749663 | — | IC50 | = | 27440.0 | nM | 4.56 |
| CHEMBL4746910 | — | IC50 | = | 32290.0 | nM | 4.49 |