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Assay Detail

CHEMBL4733469

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Binding
Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 9 (CHEMBL3594)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion.
Bouzina A,Berredjem M,Nocentini A,Bua S,Bouaziz Z,Jose J,Le Borgne M,Marminon C,Gratteri P,Supuran CT
Eur J Med Chem (2021) 209 : 112875 -112875
PubMed 33059188 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 4.87 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.60
CHEMBL4782653 1 5.87
CHEMBL1221925 1 5.62
CHEMBL4747211 1 5.55
CHEMBL4760795 1 5.54
CHEMBL4757527 1 5.08
CHEMBL4783894 1 4.87
CHEMBL4750896 1 4.78
CHEMBL4762664 1 4.77
CHEMBL4793537 1 4.56
CHEMBL4754929 1 4.53
CHEMBL4760657 1 4.52
CHEMBL4759493 1 4.51
CHEMBL4798972 1 4.47
CHEMBL4791718 1 4.41
CHEMBL4780621 1 4.35
CHEMBL4798703 1 4.33
CHEMBL4778728 1 4.29
CHEMBL4794500 1 4.26
CHEMBL4756518 1 4.21
CHEMBL4786348 1 4.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE Ki = 25.0 nM 7.60
CHEMBL4782653 Ki = 1340.0 nM 5.87
CHEMBL1221925 Ki = 2370.0 nM 5.62
CHEMBL4747211 Ki = 2810.0 nM 5.55
CHEMBL4760795 Ki = 2850.0 nM 5.54
CHEMBL4757527 Ki = 8410.0 nM 5.08
CHEMBL4783894 Ki = 13400.0 nM 4.87
CHEMBL4750896 Ki = 16800.0 nM 4.78
CHEMBL4762664 Ki = 17100.0 nM 4.77
CHEMBL4793537 Ki = 27800.0 nM 4.56
CHEMBL4754929 Ki = 29600.0 nM 4.53
CHEMBL4760657 Ki = 30400.0 nM 4.52
CHEMBL4759493 Ki = 31000.0 nM 4.51
CHEMBL4798972 Ki = 34100.0 nM 4.47
CHEMBL4791718 Ki = 38700.0 nM 4.41
CHEMBL4780621 Ki = 44300.0 nM 4.35
CHEMBL4798703 Ki = 46700.0 nM 4.33
CHEMBL4778728 Ki = 51400.0 nM 4.29
CHEMBL4794500 Ki = 54300.0 nM 4.26
CHEMBL4756518 Ki = 61200.0 nM 4.21
CHEMBL4786348 Ki = 68200.0 nM 4.17