Assay Detail
Binding
CHEMBL4733649
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Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.47 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.88 |
| CHEMBL4754406 | — | — | 1 | 6.85 |
| CHEMBL4763059 | — | — | 1 | 6.76 |
| CHEMBL4790676 | — | — | 1 | 6.74 |
| CHEMBL4780951 | — | — | 1 | 6.71 |
| CHEMBL4790377 | — | — | 1 | 6.67 |
| CHEMBL4761194 | — | — | 1 | 6.62 |
| CHEMBL56367 | NIMESULIDE | 4.0 | 1 | 5.77 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.27 |
| CHEMBL4780636 | — | — | 1 | - |
| CHEMBL4785750 | — | — | 1 | - |
| CHEMBL4745350 | — | — | 1 | - |
| CHEMBL4797164 | — | — | 1 | - |
| CHEMBL4758387 | — | — | 1 | - |
| CHEMBL4781090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4754406 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4763059 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4790676 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL4780951 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4790377 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL4761194 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL56367 | NIMESULIDE | IC50 | = | 1684.0 | nM | 5.77 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 5326.0 | nM | 5.27 |
| CHEMBL4780636 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4785750 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4745350 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4797164 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4758387 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4781090 | — | IC50 | > | 100000.0 | nM | - |