Assay Detail
Binding
CHEMBL4733696
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Inhibition of GSK3beta (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PROTACs suppression of GSK-3β, a crucial kinase in neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.69 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | — | 1 | 8.40 |
| CHEMBL3545157 | TIDEGLUSIB | 2.0 | 1 | 8.30 |
| CHEMBL2177161 | — | — | 1 | 8.30 |
| CHEMBL412142 | LADUVIGLUSIB | 1.0 | 1 | 8.15 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 7.64 |
| CHEMBL405759 | — | — | 1 | 7.52 |
| CHEMBL102714 | SB-216763 | — | 1 | 7.47 |
| CHEMBL284861 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50894 | ALSTERPAULLONE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3545157 | TIDEGLUSIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2177161 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL405759 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL102714 | SB-216763 | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL284861 | — | IC50 | = | 2000.0 | nM | 5.70 |