Assay Detail
Functional
CHEMBL4733902
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Antiproliferative activity against human SK-OV-3 cells by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.91 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4741664 | — | — | 1 | 6.50 |
| CHEMBL4752111 | — | — | 1 | 6.19 |
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 5.86 |
| CHEMBL4782106 | — | — | 1 | 5.73 |
| CHEMBL4746665 | — | — | 1 | 5.62 |
| CHEMBL4756146 | — | — | 1 | 5.39 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.20 |
| CHEMBL4764397 | — | — | 1 | 5.13 |
| CHEMBL4754337 | — | — | 1 | 5.06 |
| CHEMBL4741414 | — | — | 1 | 5.05 |
| CHEMBL4744058 | — | — | 1 | 4.90 |
| CHEMBL4755024 | — | — | 1 | 4.87 |
| CHEMBL4751722 | — | — | 1 | 4.80 |
| CHEMBL4763550 | — | — | 1 | 4.77 |
| CHEMBL4760565 | — | — | 1 | 4.70 |
| CHEMBL4740633 | — | — | 1 | 4.69 |
| CHEMBL4796994 | — | — | 1 | 4.63 |
| CHEMBL4789209 | — | — | 1 | 4.62 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.58 |
| CHEMBL4783067 | — | — | 1 | 4.58 |
| CHEMBL4760878 | — | — | 1 | 4.57 |
| CHEMBL4786306 | — | — | 1 | 4.54 |
| CHEMBL4777612 | — | — | 1 | 4.53 |
| CHEMBL4795012 | — | — | 1 | 4.53 |
| CHEMBL4761339 | — | — | 1 | 4.52 |
| CHEMBL4755349 | — | — | 1 | 4.50 |
| CHEMBL4752957 | — | — | 1 | 4.47 |
| CHEMBL4744657 | — | — | 1 | 4.47 |
| CHEMBL4765013 | — | — | 1 | 4.42 |
| CHEMBL4791535 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4741664 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4752111 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL43482 | MITONAFIDE | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4782106 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4746665 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4756146 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL4764397 | — | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL4754337 | — | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL4741414 | — | IC50 | = | 8870.0 | nM | 5.05 |
| CHEMBL4744058 | — | IC50 | = | 12670.0 | nM | 4.90 |
| CHEMBL4755024 | — | IC50 | = | 13440.0 | nM | 4.87 |
| CHEMBL4751722 | — | IC50 | = | 15940.0 | nM | 4.80 |
| CHEMBL4763550 | — | IC50 | = | 16810.0 | nM | 4.77 |
| CHEMBL4760565 | — | IC50 | = | 19910.0 | nM | 4.70 |
| CHEMBL4740633 | — | IC50 | = | 20430.0 | nM | 4.69 |
| CHEMBL4796994 | — | IC50 | = | 23190.0 | nM | 4.63 |
| CHEMBL4789209 | — | IC50 | = | 24070.0 | nM | 4.62 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 26340.0 | nM | 4.58 |
| CHEMBL4783067 | — | IC50 | = | 26260.0 | nM | 4.58 |
| CHEMBL4760878 | — | IC50 | = | 27020.0 | nM | 4.57 |
| CHEMBL4786306 | — | IC50 | = | 28920.0 | nM | 4.54 |
| CHEMBL4777612 | — | IC50 | = | 29650.0 | nM | 4.53 |
| CHEMBL4795012 | — | IC50 | = | 29520.0 | nM | 4.53 |
| CHEMBL4761339 | — | IC50 | = | 30390.0 | nM | 4.52 |
| CHEMBL4755349 | — | IC50 | = | 31380.0 | nM | 4.50 |
| CHEMBL4752957 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL4744657 | — | IC50 | = | 33620.0 | nM | 4.47 |
| CHEMBL4765013 | — | IC50 | = | 38160.0 | nM | 4.42 |
| CHEMBL4791535 | — | IC50 | = | 40350.0 | nM | 4.39 |
| CHEMBL4783808 | — | IC50 | = | 44770.0 | nM | 4.35 |
| CHEMBL4747821 | — | IC50 | = | 1224000.0 | nM | - |
| CHEMBL4763485 | — | IC50 | > | 50000.0 | nM | - |