Assay Detail
Functional
CHEMBL4733903
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Antiproliferative activity against human A549 cells by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.90 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 7.92 |
| CHEMBL4741664 | — | — | 1 | 6.57 |
| CHEMBL4782106 | — | — | 1 | 6.39 |
| CHEMBL4752111 | — | — | 1 | 5.97 |
| CHEMBL4746665 | — | — | 1 | 5.70 |
| CHEMBL4756146 | — | — | 1 | 5.18 |
| CHEMBL4754337 | — | — | 1 | 5.12 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.10 |
| CHEMBL4764397 | — | — | 1 | 4.78 |
| CHEMBL4783067 | — | — | 1 | 4.76 |
| CHEMBL4747821 | — | — | 1 | 4.68 |
| CHEMBL4760565 | — | — | 1 | 4.65 |
| CHEMBL4740633 | — | — | 1 | 4.61 |
| CHEMBL4789209 | — | — | 1 | 4.57 |
| CHEMBL4763550 | — | — | 1 | 4.50 |
| CHEMBL4783808 | — | — | 1 | 4.48 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.46 |
| CHEMBL4744657 | — | — | 1 | 4.43 |
| CHEMBL4796994 | — | — | 1 | 4.42 |
| CHEMBL4760878 | — | — | 1 | 4.41 |
| CHEMBL4777612 | — | — | 1 | 4.40 |
| CHEMBL4744058 | — | — | 1 | 4.39 |
| CHEMBL4741414 | — | — | 1 | 4.38 |
| CHEMBL4786306 | — | — | 1 | 4.38 |
| CHEMBL4765013 | — | — | 1 | 4.37 |
| CHEMBL4791535 | — | — | 1 | 4.35 |
| CHEMBL4755024 | — | — | 1 | 4.34 |
| CHEMBL4795012 | — | — | 1 | 4.33 |
| CHEMBL4751722 | — | — | 1 | 4.32 |
| CHEMBL4755349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4741664 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4782106 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4752111 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4746665 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4756146 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL4754337 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL4764397 | — | IC50 | = | 16510.0 | nM | 4.78 |
| CHEMBL4783067 | — | IC50 | = | 17360.0 | nM | 4.76 |
| CHEMBL4747821 | — | IC50 | = | 20770.0 | nM | 4.68 |
| CHEMBL4760565 | — | IC50 | = | 22530.0 | nM | 4.65 |
| CHEMBL4740633 | — | IC50 | = | 24680.0 | nM | 4.61 |
| CHEMBL4789209 | — | IC50 | = | 26910.0 | nM | 4.57 |
| CHEMBL4763550 | — | IC50 | = | 31330.0 | nM | 4.50 |
| CHEMBL4783808 | — | IC50 | = | 33360.0 | nM | 4.48 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 34470.0 | nM | 4.46 |
| CHEMBL4744657 | — | IC50 | = | 36840.0 | nM | 4.43 |
| CHEMBL4796994 | — | IC50 | = | 38390.0 | nM | 4.42 |
| CHEMBL4760878 | — | IC50 | = | 38590.0 | nM | 4.41 |
| CHEMBL4777612 | — | IC50 | = | 39960.0 | nM | 4.40 |
| CHEMBL4744058 | — | IC50 | = | 40370.0 | nM | 4.39 |
| CHEMBL4741414 | — | IC50 | = | 42140.0 | nM | 4.38 |
| CHEMBL4786306 | — | IC50 | = | 41760.0 | nM | 4.38 |
| CHEMBL4765013 | — | IC50 | = | 42910.0 | nM | 4.37 |
| CHEMBL4791535 | — | IC50 | = | 44520.0 | nM | 4.35 |
| CHEMBL4755024 | — | IC50 | = | 45620.0 | nM | 4.34 |
| CHEMBL4795012 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL4751722 | — | IC50 | = | 47740.0 | nM | 4.32 |
| CHEMBL4755349 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4761339 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4752957 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4763485 | — | IC50 | > | 50000.0 | nM | - |