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Assay Detail

CHEMBL4734028

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Functional
Antiproliferative activity against human MCF7 cells assessed as cell viability after 24 hrs
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?
Rassias G,Leonardi S,Rigopoulou D,Vachlioti E,Afratis K,Piperigkou Z,Koutsakis C,Karamanos NK,Gavras H,Papaioannou D
Eur J Med Chem (2021) 210 : 112948 -112948
PubMed 33139111 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.62 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4760768 1 7.16
CHEMBL4744780 1 6.80
CHEMBL4749244 1 6.48
CHEMBL32749 FERULATE -1.0 1 6.44
CHEMBL4754189 1 6.14
CHEMBL4750888 1 6.07
CHEMBL4800357 1 6.03
CHEMBL4787094 1 5.92
CHEMBL99869 1 5.67
CHEMBL4740222 1 5.67
CHEMBL38 TRETINOIN 4.0 1 5.21
CHEMBL4749497 1 4.28
CHEMBL4747403 1 4.19
CHEMBL4759582 1 4.19
CHEMBL4797511 1 4.04
CHEMBL4784225 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4760768 IC50 = 70.0 nM 7.16
CHEMBL4744780 IC50 = 160.0 nM 6.80
CHEMBL4749244 IC50 = 330.0 nM 6.48
CHEMBL32749 FERULATE IC50 = 360.0 nM 6.44
CHEMBL4754189 IC50 = 730.0 nM 6.14
CHEMBL4750888 IC50 = 860.0 nM 6.07
CHEMBL4800357 IC50 = 930.0 nM 6.03
CHEMBL4787094 IC50 = 1210.0 nM 5.92
CHEMBL99869 IC50 = 2140.0 nM 5.67
CHEMBL4740222 IC50 = 2120.0 nM 5.67
CHEMBL38 TRETINOIN IC50 = 6140.0 nM 5.21
CHEMBL4749497 IC50 = 53000.0 nM 4.28
CHEMBL4747403 IC50 = 65000.0 nM 4.19
CHEMBL4759582 IC50 = 64000.0 nM 4.19
CHEMBL4797511 IC50 = 91000.0 nM 4.04
CHEMBL4784225 IC50 = 407000.0 nM -