Assay Detail
Functional
CHEMBL4734029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.94 | 10.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4787094 | — | — | 1 | 10.23 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.52 |
| CHEMBL4759582 | — | — | 1 | 8.30 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.00 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.00 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.62 |
| CHEMBL99869 | — | — | 1 | 7.10 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL417 | EPIRUBICIN | 4.0 | 1 | 6.82 |
| CHEMBL4754189 | — | — | 1 | 6.37 |
| CHEMBL4749497 | — | — | 1 | 6.11 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.05 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.05 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.68 |
| CHEMBL4749244 | — | — | 1 | 5.23 |
| CHEMBL4784225 | — | — | 1 | 5.16 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 4.97 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 4.84 |
| CHEMBL32749 | FERULATE | -1.0 | 1 | 4.82 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 4.80 |
| CHEMBL130517 | FR-173657 | — | 1 | 4.70 |
| CHEMBL4750888 | — | — | 1 | 4.66 |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | 4.56 |
| CHEMBL2396661 | ALPELISIB | 4.0 | 1 | 4.20 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 4.20 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.18 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.16 |
| CHEMBL4740222 | — | — | 1 | 4.07 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | 4.0 | 1 | - |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4787094 | — | IC50 | = | 0.0594 | nM | 10.23 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4759582 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL99869 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL417 | EPIRUBICIN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4754189 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4749497 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4749244 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4784225 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL554 | LAPATINIB | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL32749 | FERULATE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL38 | TRETINOIN | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL130517 | FR-173657 | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4750888 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3545110 | RIBOCICLIB | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL2396661 | ALPELISIB | IC50 | = | 62900.0 | nM | 4.20 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 62500.0 | nM | 4.20 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 69700.0 | nM | 4.16 |
| CHEMBL4740222 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | IC50 | = | 195500.0 | nM | - |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 196300.0 | nM | - |
| CHEMBL4760768 | — | IC50 | = | 520000.0 | nM | - |
| CHEMBL4797511 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL4747403 | — | IC50 | = | 193000.0 | nM | - |
| CHEMBL4800357 | — | IC50 | = | 650000.0 | nM | - |
| CHEMBL4744780 | — | IC50 | = | 450000.0 | nM | - |