Assay Detail
Binding
CHEMBL4735459
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Inhibition of PARP1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.05 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744783 | — | — | 1 | 8.24 |
| CHEMBL4758337 | — | — | 1 | 8.14 |
| CHEMBL4745923 | — | — | 1 | 7.97 |
| CHEMBL4761383 | — | — | 1 | 7.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744783 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4758337 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4745923 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL4761383 | — | IC50 | = | 13.8 | nM | 7.86 |