Assay Detail
Binding
CHEMBL4735557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membrane measured after 60 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT receptor antagonist with therapeutic interest in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.16 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4746584 | — | — | 1 | 8.37 |
| CHEMBL3286580 | IDALOPIRDINE | 3.0 | 1 | 8.16 |
| CHEMBL4788250 | — | — | 1 | 7.94 |
| CHEMBL4750581 | — | — | 1 | - |
| CHEMBL4744490 | — | — | 1 | - |
| CHEMBL4761198 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4746584 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL3286580 | IDALOPIRDINE | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL4788250 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL4750581 | — | Ki | - | — | - | |
| CHEMBL4744490 | — | Ki | - | — | - | |
| CHEMBL4761198 | — | Ki | - | — | - |