Assay Detail
ADMET
CHEMBL4736130
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Displacement of [3H]-5-CT from human 5HT7b expressed in HEK293 cell membranes incubated for 1 hr by micro-beta plate reader based analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Imidazopyridine-Based 5-HT Receptor Neutral Antagonists: Impact of N-Benzyl and N-Phenylsulfonyl Fragments on Different Receptor Conformational States.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.29 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4799851 | — | — | 1 | 5.51 |
| CHEMBL4756814 | — | — | 1 | 5.42 |
| CHEMBL4742804 | — | — | 1 | 5.41 |
| CHEMBL4760105 | — | — | 1 | 5.37 |
| CHEMBL4777550 | — | — | 1 | 5.18 |
| CHEMBL1083390 | INTEPIRDINE | 3.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4799851 | — | Ki | = | 3084.0 | nM | 5.51 |
| CHEMBL4756814 | — | Ki | = | 3763.0 | nM | 5.42 |
| CHEMBL4742804 | — | Ki | = | 3904.0 | nM | 5.41 |
| CHEMBL4760105 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL4777550 | — | Ki | = | 6642.0 | nM | 5.18 |
| CHEMBL1083390 | INTEPIRDINE | Ki | = | 14230.0 | nM | 4.85 |