Assay Detail
Functional
CHEMBL4736327
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Antiviral activity against HCV infected in human Huh-7 cells assessed as reduction in viral replication measured after 48 hrs by luciferase reporter gene assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of liver-specific gemcitabine prodrugs for potential treatment of hepatitis C virus infection and hepatocellular carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.24 | 10.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 10.51 |
| CHEMBL4760100 | — | — | 1 | 8.00 |
| CHEMBL4784303 | — | — | 1 | 7.89 |
| CHEMBL4761809 | — | — | 1 | 7.76 |
| CHEMBL4760817 | — | — | 1 | 7.71 |
| CHEMBL4744416 | — | — | 1 | 7.59 |
| CHEMBL4784169 | — | — | 1 | 7.42 |
| CHEMBL4786644 | — | — | 1 | 7.37 |
| CHEMBL4751753 | — | — | 1 | 7.33 |
| CHEMBL4742182 | — | — | 1 | 7.33 |
| CHEMBL4751638 | — | — | 1 | 7.31 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.24 |
| CHEMBL4742837 | — | — | 1 | 7.23 |
| CHEMBL4780873 | — | — | 1 | 7.23 |
| CHEMBL4750295 | — | — | 1 | 7.22 |
| CHEMBL4798258 | — | — | 1 | 7.22 |
| CHEMBL4778602 | — | — | 1 | 7.13 |
| CHEMBL4778476 | — | — | 1 | 7.11 |
| CHEMBL4740794 | — | — | 1 | 7.07 |
| CHEMBL4792135 | — | — | 1 | 7.04 |
| CHEMBL4800293 | — | — | 1 | 7.03 |
| CHEMBL4740253 | — | — | 1 | 6.90 |
| CHEMBL4763812 | — | — | 1 | 6.90 |
| CHEMBL4744384 | — | — | 1 | 6.84 |
| CHEMBL4746402 | — | — | 1 | 6.79 |
| CHEMBL4779910 | — | — | 1 | 6.75 |
| CHEMBL4790892 | — | — | 1 | 6.73 |
| CHEMBL4788697 | — | — | 1 | 6.47 |
| CHEMBL4785386 | — | — | 1 | 6.35 |
| CHEMBL4781031 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023898 | DACLATASVIR | IC50 | = | 0.031 | nM | 10.51 |
| CHEMBL4760100 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4784303 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL4761809 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL4760817 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL4744416 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL4784169 | — | IC50 | = | 37.6 | nM | 7.42 |
| CHEMBL4786644 | — | IC50 | = | 43.1 | nM | 7.37 |
| CHEMBL4751753 | — | IC50 | = | 46.7 | nM | 7.33 |
| CHEMBL4742182 | — | IC50 | = | 46.4 | nM | 7.33 |
| CHEMBL4751638 | — | IC50 | = | 49.3 | nM | 7.31 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4742837 | — | IC50 | = | 58.6 | nM | 7.23 |
| CHEMBL4780873 | — | IC50 | = | 58.4 | nM | 7.23 |
| CHEMBL4750295 | — | IC50 | = | 59.8 | nM | 7.22 |
| CHEMBL4798258 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4778602 | — | IC50 | = | 73.4 | nM | 7.13 |
| CHEMBL4778476 | — | IC50 | = | 77.5 | nM | 7.11 |
| CHEMBL4740794 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4792135 | — | IC50 | = | 91.5 | nM | 7.04 |
| CHEMBL4800293 | — | IC50 | = | 93.5 | nM | 7.03 |
| CHEMBL4740253 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4763812 | — | IC50 | = | 126.7 | nM | 6.90 |
| CHEMBL4744384 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4746402 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4779910 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4790892 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4788697 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4785386 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL4781031 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4783975 | — | IC50 | - | — | - |