Assay Detail
Binding
CHEMBL4736571
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Inhibition of yeast Cdc48 T532C mutant assessed as reduction in ATPase activity measured after 60 mins by biomol green reagent based assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.63 | 4.85 |
| IC50(app) | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4762311 | — | — | 1 | 4.85 |
| CHEMBL4756916 | — | — | 1 | 4.66 |
| CHEMBL4788535 | — | — | 1 | 4.62 |
| CHEMBL4792077 | — | — | 1 | 4.58 |
| CHEMBL4752271 | — | — | 1 | 4.46 |
| CHEMBL2078794 | — | — | 1 | - |
| CHEMBL1231371 | — | — | 1 | - |
| CHEMBL4795080 | — | — | 1 | - |
| CHEMBL4749210 | — | — | 1 | - |
| CHEMBL4757121 | — | — | 1 | - |
| CHEMBL4790925 | — | — | 1 | - |
| CHEMBL4759891 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4762311 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4756916 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4788535 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4792077 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4752271 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2078794 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1231371 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4795080 | — | IC50(app) | - | — | - | |
| CHEMBL4749210 | — | IC50(app) | - | — | - | |
| CHEMBL4757121 | — | IC50(app) | - | — | - | |
| CHEMBL4790925 | — | IC50(app) | - | — | - | |
| CHEMBL4759891 | — | IC50(app) | - | — | - |