Assay Detail
Binding
CHEMBL4736698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by TopCount scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bicyclic Ligand-Biased Agonists of S1P: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 10.73 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3806205 | — | — | 1 | 11.00 |
| CHEMBL4752394 | — | — | 1 | 10.80 |
| CHEMBL4786296 | — | — | 1 | 10.40 |
| CHEMBL114606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3806205 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4752394 | — | IC50 | = | 0.016 | nM | 10.80 |
| CHEMBL4786296 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL114606 | — | IC50 | = | 0.008 | nM | - |