Assay Detail
Binding
CHEMBL4736702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated for 50 mins by fluorescence based confocal laser scanning microscopic analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bicyclic Ligand-Biased Agonists of S1P: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.46 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114606 | — | — | 1 | 10.15 |
| CHEMBL3806205 | — | — | 1 | 9.96 |
| CHEMBL4786296 | — | — | 1 | 9.40 |
| CHEMBL4752394 | — | — | 1 | 8.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114606 | — | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL3806205 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL4786296 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4752394 | — | EC50 | = | 4.9 | nM | 8.31 |