Assay Detail
Binding
CHEMBL4736704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bicyclic Ligand-Biased Agonists of S1P: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.91 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114606 | — | — | 1 | 10.70 |
| CHEMBL4752394 | — | — | 1 | 8.57 |
| CHEMBL4786296 | — | — | 1 | 8.28 |
| CHEMBL3806205 | — | — | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114606 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4752394 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4786296 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3806205 | — | EC50 | = | 8.2 | nM | 8.09 |