Assay Detail
Functional
CHEMBL4736709
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Antimigratory activity against human T cells assessed as inhibition of S1P-induced T cell migration preincubated for 10 mins followed by addition of S1P measured after 120 mins by calcein-AM dye based fluorescence analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bicyclic Ligand-Biased Agonists of S1P: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.77 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752394 | — | — | 1 | 9.15 |
| CHEMBL114606 | — | — | 1 | 8.92 |
| CHEMBL3806205 | — | — | 1 | 8.60 |
| CHEMBL4786296 | — | — | 1 | 8.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752394 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL114606 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3806205 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4786296 | — | IC50 | = | 4.1 | nM | 8.39 |