Assay Detail
Functional
CHEMBL4736780
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Antiproliferation activity against human SK-BR-3 cells incubated for 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFR mutant cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.89 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.67 |
| CHEMBL4759112 | — | — | 1 | 5.25 |
| CHEMBL4758761 | — | — | 1 | 4.80 |
| CHEMBL4744985 | — | — | 1 | 4.70 |
| CHEMBL4794670 | — | — | 1 | 4.69 |
| CHEMBL4758842 | — | — | 1 | 4.61 |
| CHEMBL4759072 | — | — | 1 | 4.51 |
| CHEMBL4759697 | — | — | 1 | - |
| CHEMBL4794998 | — | — | 1 | - |
| CHEMBL4783641 | — | — | 1 | - |
| CHEMBL4793338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL4759112 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL4758761 | — | IC50 | = | 15970.0 | nM | 4.80 |
| CHEMBL4744985 | — | IC50 | = | 19970.0 | nM | 4.70 |
| CHEMBL4794670 | — | IC50 | = | 20240.0 | nM | 4.69 |
| CHEMBL4758842 | — | IC50 | = | 24770.0 | nM | 4.61 |
| CHEMBL4759072 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL4759697 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4794998 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4783641 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4793338 | — | IC50 | > | 50000.0 | nM | - |