Assay Detail
Binding
CHEMBL4736790
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Inhibition of EGFR exon19 deletion/T790M/C797S double mutant (unknown origin) expressed in Ba/F3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFR mutant cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.80 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.23 |
| CHEMBL4759112 | — | — | 1 | 6.05 |
| CHEMBL4759072 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4759112 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4759072 | — | IC50 | = | 7610.0 | nM | 5.12 |