Assay Detail
ADMET
CHEMBL4736795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
cytotoxicity against human HL-7702 cells assessed as reduction of cell viability incubated for 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFR mutant cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.53 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4759112 | — | — | 1 | 5.79 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.26 |
| CHEMBL4759697 | — | — | 1 | - |
| CHEMBL4794998 | — | — | 1 | - |
| CHEMBL4783641 | — | — | 1 | - |
| CHEMBL4793338 | — | — | 1 | - |
| CHEMBL4759072 | — | — | 1 | - |
| CHEMBL4744985 | — | — | 1 | - |
| CHEMBL4758842 | — | — | 1 | - |
| CHEMBL4794670 | — | — | 1 | - |
| CHEMBL4758761 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4759112 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL4759697 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4794998 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4783641 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4793338 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4759072 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4744985 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4758842 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4794670 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4758761 | — | IC50 | > | 25000.0 | nM | - |