Assay Detail
Binding
CHEMBL4736948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CAH2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.66 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 9.03 |
| CHEMBL4799997 | — | — | 1 | 7.92 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL4799997 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 960.0 | nM | 6.02 |