Assay Detail
ADMET
CHEMBL4737014
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Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol Derivatives as Glutathione Transferase Inhibitors with Favorable Selectivity and Tolerated Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.77 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1234570 | — | — | 1 | 6.30 |
| CHEMBL4748062 | — | — | 1 | 6.13 |
| CHEMBL4787180 | — | — | 1 | 6.08 |
| CHEMBL4763865 | — | — | 1 | 6.06 |
| CHEMBL4742105 | — | — | 1 | 5.97 |
| CHEMBL4759134 | — | — | 1 | 5.96 |
| CHEMBL4757112 | — | — | 1 | 5.86 |
| CHEMBL4757338 | — | — | 1 | 5.85 |
| CHEMBL4777228 | — | — | 1 | 5.80 |
| CHEMBL4757438 | — | — | 1 | 5.80 |
| CHEMBL4743025 | — | — | 1 | 5.79 |
| CHEMBL4783291 | — | — | 1 | 5.79 |
| CHEMBL4743365 | — | — | 1 | 5.76 |
| CHEMBL4794932 | — | — | 1 | 5.70 |
| CHEMBL4764480 | — | — | 1 | 5.67 |
| CHEMBL4751148 | — | — | 1 | 5.63 |
| CHEMBL4762497 | — | — | 1 | 5.63 |
| CHEMBL4797735 | — | — | 1 | 5.60 |
| CHEMBL4739867 | — | — | 1 | 5.53 |
| CHEMBL4762005 | — | — | 1 | 5.53 |
| CHEMBL4763818 | — | — | 1 | 5.27 |
| CHEMBL4797471 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1234570 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4748062 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4787180 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4763865 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4742105 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4759134 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4757112 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4757338 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4777228 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4757438 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4743025 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4783291 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4743365 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4794932 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4764480 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4751148 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4762497 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4797735 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4739867 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4762005 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4763818 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL4797471 | — | IC50 | = | 6070.0 | nM | 5.22 |