Assay Detail
Functional
CHEMBL4737019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HOS cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HOS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol Derivatives as Glutathione Transferase Inhibitors with Favorable Selectivity and Tolerated Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.59 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4763818 | — | — | 1 | 6.00 |
| CHEMBL1234570 | — | — | 1 | 5.91 |
| CHEMBL4763865 | — | — | 1 | 5.86 |
| CHEMBL4794932 | — | — | 1 | 5.75 |
| CHEMBL4777228 | — | — | 1 | 5.75 |
| CHEMBL4742105 | — | — | 1 | 5.74 |
| CHEMBL4757438 | — | — | 1 | 5.73 |
| CHEMBL4759134 | — | — | 1 | 5.72 |
| CHEMBL4743365 | — | — | 1 | 5.68 |
| CHEMBL4743025 | — | — | 1 | 5.67 |
| CHEMBL4797735 | — | — | 1 | 5.67 |
| CHEMBL4787180 | — | — | 1 | 5.63 |
| CHEMBL4751148 | — | — | 1 | 5.55 |
| CHEMBL4783291 | — | — | 1 | 5.54 |
| CHEMBL4757112 | — | — | 1 | 5.50 |
| CHEMBL4797471 | — | — | 1 | 5.48 |
| CHEMBL4762497 | — | — | 1 | 5.48 |
| CHEMBL4757338 | — | — | 1 | 5.40 |
| CHEMBL4764480 | — | — | 1 | 5.30 |
| CHEMBL4748062 | — | — | 1 | 5.06 |
| CHEMBL4739867 | — | — | 1 | 5.04 |
| CHEMBL4762005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4763818 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL1234570 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4763865 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4794932 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4777228 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4742105 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4757438 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4759134 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4743365 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4743025 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4797735 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4787180 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL4751148 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4783291 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL4757112 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4797471 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4762497 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL4757338 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL4764480 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL4748062 | — | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL4739867 | — | IC50 | = | 9060.0 | nM | 5.04 |
| CHEMBL4762005 | — | IC50 | = | 335000.0 | nM | - |