Assay Detail
Binding
CHEMBL4737436
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Inhibition of recombinant EpsteinBarr virus Transmembrane domain 5 of latent membrane protein 1 transformed into Escherichia coli FHK12 cells assessed as disruption of oligomerization by measuring ToxR transcription activity assay
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human gammaherpesvirus 4 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting the transmembrane domain 5 of latent membrane protein 1 using small molecule modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.04 | 6.22 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185063 | — | — | 2 | 6.22 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.04 |
| CHEMBL22866 | — | — | 1 | 4.51 |
| CHEMBL185175 | — | — | 1 | 4.38 |
| CHEMBL1080610 | — | — | 1 | - |
| CHEMBL1963636 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185063 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL22866 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL185175 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1080610 | — | IC50 | = | 111500.0 | nM | - |
| CHEMBL1963636 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL185063 | — | Inhibition | - | % | - |