Assay Detail
Binding
CHEMBL4737687
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Inhibition of recombinant human HDAC1 using Ac-LGK(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90 mins by fluorescence based assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.37 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.75 |
| CHEMBL191482 | AR-42 | 2.0 | 1 | 7.70 |
| CHEMBL4762512 | — | — | 1 | 6.77 |
| CHEMBL4758506 | — | — | 1 | 5.85 |
| CHEMBL4761013 | — | — | 1 | 5.31 |
| CHEMBL4741326 | — | — | 1 | 5.00 |
| CHEMBL4776127 | — | — | 1 | 5.00 |
| CHEMBL4759268 | — | — | 1 | 4.72 |
| CHEMBL4763919 | — | — | 1 | 4.70 |
| CHEMBL4751174 | — | — | 1 | 4.58 |
| CHEMBL4799406 | — | — | 1 | 4.57 |
| CHEMBL4748500 | — | — | 1 | 4.50 |
| CHEMBL4752663 | — | — | 1 | 4.41 |
| CHEMBL4751615 | — | — | 1 | 4.35 |
| CHEMBL356769 | TUBACIN | — | 1 | - |
| CHEMBL4747652 | — | — | 1 | - |
| CHEMBL4776825 | — | — | 1 | - |
| CHEMBL4784844 | — | — | 1 | - |
| CHEMBL4792528 | — | — | 1 | - |
| CHEMBL4776962 | — | — | 1 | - |
| CHEMBL4760192 | — | — | 1 | - |
| CHEMBL4748151 | — | — | 1 | - |
| CHEMBL4740957 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL191482 | AR-42 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4762512 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4758506 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4761013 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4741326 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4776127 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4759268 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4763919 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4751174 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4799406 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4748500 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4752663 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4751615 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL356769 | TUBACIN | IC50 | - | — | - | |
| CHEMBL4747652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4776825 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4784844 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4792528 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4776962 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4760192 | — | IC50 | - | — | - | |
| CHEMBL4748151 | — | IC50 | - | — | - | |
| CHEMBL4740957 | — | IC50 | > | 10000.0 | nM | - |