Assay Detail
Binding
CHEMBL4737693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC8 using Ac-LGK(TFA)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90 mins by fluorescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.76 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761013 | — | — | 1 | 7.15 |
| CHEMBL4748500 | — | — | 1 | 7.14 |
| CHEMBL4799406 | — | — | 1 | 7.06 |
| CHEMBL191482 | AR-42 | 2.0 | 1 | 6.77 |
| CHEMBL4751615 | — | — | 1 | 5.68 |
| CHEMBL356769 | TUBACIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761013 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4748500 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4799406 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL191482 | AR-42 | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4751615 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL356769 | TUBACIN | IC50 | - | — | - |