Assay Detail
Binding
CHEMBL4737695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Class 1 histone deacetylase in human THP-1 cells using Ac-LGK(Ac)-AMC as substrate incubated for 3 hrs followed by 50 uM SAHA addition and measured after 1 hr by fluorescence based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.52 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191482 | AR-42 | 2.0 | 1 | 6.52 |
| CHEMBL4748500 | — | — | 1 | - |
| CHEMBL4799406 | — | — | 1 | - |
| CHEMBL4761013 | — | — | 1 | - |
| CHEMBL4751615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191482 | AR-42 | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4748500 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4799406 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4761013 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4751615 | — | IC50 | > | 30000.0 | nM | - |