Assay Detail
Functional
CHEMBL4737828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against asexual stage Plasmodium falciparum NF54 assessed as inhibition of male gametes formation in ookinete medium observed at day 14 in presence of 10% human serum by haemocytometer based light microscopic analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.50 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4764956 | — | — | 1 | 6.61 |
| CHEMBL4743418 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4764956 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL4743418 | — | IC50 | = | 405.0 | nM | 6.39 |