Assay Detail
Functional
CHEMBL4737829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum NF54 transfected with GFP-Luc infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation pretreated for 48 hrs followed by [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting method
32
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.81 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756352 | — | — | 1 | 7.85 |
| CHEMBL4755397 | — | — | 1 | 7.85 |
| CHEMBL4797995 | — | — | 1 | 7.82 |
| CHEMBL2058833 | GANAPLACIDE | 2.0 | 1 | 7.80 |
| CHEMBL4763437 | — | — | 1 | 7.77 |
| CHEMBL2041980 | MMV-048 | 2.0 | 1 | 7.55 |
| CHEMBL4750683 | — | — | 1 | 7.52 |
| CHEMBL4759714 | — | — | 1 | 7.48 |
| CHEMBL4799348 | — | — | 1 | 7.44 |
| CHEMBL4764956 | — | — | 3 | 7.36 |
| CHEMBL4791555 | — | — | 1 | 7.36 |
| CHEMBL4780165 | — | — | 1 | 7.35 |
| CHEMBL4743418 | — | — | 2 | 7.24 |
| CHEMBL4745404 | — | — | 1 | 7.12 |
| CHEMBL4741532 | — | — | 1 | 6.99 |
| CHEMBL4795434 | — | — | 1 | 6.96 |
| CHEMBL4754515 | — | — | 1 | 6.89 |
| CHEMBL4753689 | — | — | 1 | 6.44 |
| CHEMBL4756151 | — | — | 1 | 6.07 |
| CHEMBL4760020 | — | — | 1 | 5.60 |
| CHEMBL4744339 | — | — | 1 | 5.57 |
| CHEMBL4756502 | — | — | 1 | 5.51 |
| CHEMBL4755921 | — | — | 1 | 5.38 |
| CHEMBL4761821 | — | — | 1 | 5.34 |
| CHEMBL4777583 | — | — | 1 | 5.29 |
| CHEMBL4794192 | — | — | 1 | - |
| CHEMBL4790005 | — | — | 1 | - |
| CHEMBL4779239 | — | — | 1 | - |
| CHEMBL4748764 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756352 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4755397 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4797995 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2058833 | GANAPLACIDE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4763437 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2041980 | MMV-048 | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4750683 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4759714 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4799348 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4764956 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4791555 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4780165 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4743418 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4745404 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4741532 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4795434 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4754515 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4764956 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4753689 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4756151 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4760020 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4744339 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4756502 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4755921 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4764956 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4761821 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4777583 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4794192 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL4790005 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL4779239 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL4748764 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL4743418 | — | IC50 | = | 230000.0 | nM | - |