Assay Detail
Binding
CHEMBL4737841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG incubated for 4 hrs by fluorescene microplate reader assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.73 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756352 | — | — | 1 | 5.80 |
| CHEMBL4743418 | — | — | 1 | 5.66 |
| CHEMBL4764956 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756352 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4743418 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4764956 | — | IC50 | > | 30000.0 | nM | - |