Assay Detail
Binding
CHEMBL4737876
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Binding affinity to CARL I1139K mutant in multidrug-resistant Plasmodium falciparum infected in human O-postive erythrocytes assessed as inhibition of parasite growth measured after 72 hrs by SYBR Green 1 staining based fluorescence assay
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.51 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745404 | — | — | 2 | 5.96 |
| CHEMBL4759714 | — | — | 1 | 5.93 |
| CHEMBL4743418 | — | — | 1 | 5.71 |
| CHEMBL4784415 | — | — | 1 | 5.63 |
| CHEMBL2058833 | GANAPLACIDE | 2.0 | 1 | 5.39 |
| CHEMBL2431809 | — | — | 1 | 5.32 |
| CHEMBL4764956 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745404 | — | IC50 | = | 1101.8 | nM | 5.96 |
| CHEMBL4759714 | — | IC50 | = | 1168.0 | nM | 5.93 |
| CHEMBL4743418 | — | IC50 | = | 1936.6 | nM | 5.71 |
| CHEMBL4784415 | — | IC50 | = | 2366.5 | nM | 5.63 |
| CHEMBL2058833 | GANAPLACIDE | IC50 | = | 4103.6 | nM | 5.39 |
| CHEMBL2431809 | — | IC50 | = | 4831.3 | nM | 5.32 |
| CHEMBL4745404 | — | IC50 | = | 5126.7 | nM | 5.29 |
| CHEMBL4764956 | — | IC50 | = | 13342.2 | nM | 4.88 |