Assay Detail
Binding
CHEMBL4737877
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Binding affinity to CARL E1104K mutant in multidrug-resistant Plasmodium falciparum infected in human O-postive erythrocytes assessed as inhibition of parasite growth measured after 72 hrs by SYBR Green 1 staining based fluorescence assay
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.88 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745404 | — | — | 2 | 8.05 |
| CHEMBL4764956 | — | — | 1 | 7.81 |
| CHEMBL4784415 | — | — | 1 | 7.57 |
| CHEMBL2058833 | GANAPLACIDE | 2.0 | 1 | 6.96 |
| CHEMBL2431809 | — | — | 1 | 6.88 |
| CHEMBL4759714 | — | — | 1 | 5.90 |
| CHEMBL4743418 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745404 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL4764956 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL4784415 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL2058833 | GANAPLACIDE | IC50 | = | 108.4 | nM | 6.96 |
| CHEMBL2431809 | — | IC50 | = | 130.7 | nM | 6.88 |
| CHEMBL4745404 | — | IC50 | = | 967.1 | nM | 6.01 |
| CHEMBL4759714 | — | IC50 | = | 1253.2 | nM | 5.90 |
| CHEMBL4743418 | — | IC50 | = | 1309.1 | nM | 5.88 |