Assay Detail
Functional
CHEMBL4738153
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Antiproliferative activity against human HT-29 cells measured after 72 hrs by sulforhodamine B assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.56 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4760646 | — | — | 1 | 4.75 |
| CHEMBL4789317 | — | — | 1 | 4.72 |
| CHEMBL4764579 | — | — | 1 | 4.69 |
| CHEMBL4740580 | — | — | 1 | 4.67 |
| CHEMBL4741703 | — | — | 1 | 4.66 |
| CHEMBL4763755 | — | — | 1 | 4.66 |
| CHEMBL4782996 | — | — | 1 | 4.65 |
| CHEMBL4755192 | — | — | 1 | 4.64 |
| CHEMBL105867 | — | — | 1 | 4.59 |
| CHEMBL4795800 | — | — | 1 | 4.59 |
| CHEMBL4764977 | — | — | 1 | 4.58 |
| CHEMBL4757989 | — | — | 1 | 4.57 |
| CHEMBL4741900 | — | — | 1 | 4.44 |
| CHEMBL4780939 | — | — | 1 | 4.44 |
| CHEMBL4743317 | — | — | 1 | 4.22 |
| CHEMBL4747886 | — | — | 1 | 4.11 |
| CHEMBL4740001 | — | — | 1 | - |
| CHEMBL4788438 | — | — | 1 | - |
| CHEMBL4777428 | — | — | 1 | - |
| CHEMBL4763044 | — | — | 1 | - |
| CHEMBL4779409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4760646 | — | IC50 | = | 17590.0 | nM | 4.75 |
| CHEMBL4789317 | — | IC50 | = | 18820.0 | nM | 4.72 |
| CHEMBL4764579 | — | IC50 | = | 20270.0 | nM | 4.69 |
| CHEMBL4740580 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL4741703 | — | IC50 | = | 22010.0 | nM | 4.66 |
| CHEMBL4763755 | — | IC50 | = | 21890.0 | nM | 4.66 |
| CHEMBL4782996 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL4755192 | — | IC50 | = | 22960.0 | nM | 4.64 |
| CHEMBL105867 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL4795800 | — | IC50 | = | 25570.0 | nM | 4.59 |
| CHEMBL4764977 | — | IC50 | = | 26430.0 | nM | 4.58 |
| CHEMBL4757989 | — | IC50 | = | 27080.0 | nM | 4.57 |
| CHEMBL4741900 | — | IC50 | = | 36420.0 | nM | 4.44 |
| CHEMBL4780939 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL4743317 | — | IC50 | = | 60500.0 | nM | 4.22 |
| CHEMBL4747886 | — | IC50 | = | 77920.0 | nM | 4.11 |
| CHEMBL4740001 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4788438 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4777428 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4763044 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4779409 | — | IC50 | > | 80000.0 | nM | - |